AG 490

(HB1424)

Product overview

  • Name
    AG 490
  • Short description
    Selective EGF receptor tyrosine kinase inhibitor
  • Biological description
    Selective EGF receptor tyrosine kinase inhibitor. Inhibits EGFR and ErbB2 (IC50 values are 2 and 13.5 µM respectively). Inhibits JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK signaling pathways. Inhibits IL-2-induced T cell proliferation. Shows anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (E)-2-Cyano-3-(3,4-dihydrophenyl)-N -(phenylmethyl)-2-propenamide
  • Molecular Weight
    294.31
  • Chemical structure
    AG 490  [133550-30-8]
  • Molecular Formula
    C17H14N2O3
  • CAS Number
    133550-30-8

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AG 490

  • JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.

    Wang LH et al (1999) J Immunol 162(7) : 3897-904.
    PubMedID: 10201908
  • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.

    Meydan N et al (1996) Nature 379(6566) : 645-8.
    PubMedID: 8628398
  • Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

    Gazit A et al (1991) J Med Chem 34(6) : 1896-907.
    PubMedID: 1676428

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