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Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (0.3 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name RSGPPGLQGRAQRLLQASGNHAAGILTM (modifications: Met-28 = C-terminal amide)
Chemical structure
Molecular Formula C120 H206 N44 O35 S
Sequence (one letter) RSGPPGLQGRAQRLLQASGNHAAGILTM
Modifications Met-28 = C-terminal amide
PubChem identifier 90473850
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)N
InChiKey SURUUKNICBOUOQ-UBNRXWOCSA-N
References for [Ala11,D-Leu15]-Orexin B References are publications that support the biological activity of the product
Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. Urbanska et al (2012) J Mol Neurosci 46(1) : 10-7 Orexin directly excites orexin neurons through orexin 2 receptor. Yamanaka (2010) J Neurosci 30(38) : 12642-52 Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Asahi et al (2003) Bioorg Med Chem Lett 13(1) : 111-3
Potent, selective OX2 receptor agonist
![[Ala11,D-Leu15]-Orexin B | [532932-99-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3407_1.png "[Ala11,D-Leu15]-Orexin B | [532932-99-3]")
Understanding purity and quality - a guide for life scientists
