Allopregnanolone

(HB0932)

Product overview

  • Name
    Allopregnanolone
  • Short description
    Potent GABAA receptor positive allosteric modulator
  • Biological description
    Potent GABAA receptor positive allosteric modulator. Endogenous neurosteroid; shows sedative, anticonvulsive, antidepressant and anxiolytic actions. Shows neurogenic effects in Alzheimer's disease and Parkinson's disease.
  • Biological action
    PAM
  • Citations

Properties

  • Chemical name
    (3α,5α)-3-Hydroxy-pregnan-20-one
  • Molecular Weight
    318.49
  • Chemical structure
    Allopregnanolone  [516-54-1]
  • Molecular Formula
    C21H34O2
  • CAS Number
    516-54-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Allopregnanolone

  • Neurosteroids: endogenous role in the human brain and therapeutic potentials.

    Reddy DS (2010) Prog Brain Res 186 : 113-37.
    PubMedID: 21094889
  • Neurosteroids act on recombinant human GABAA receptors.

    Puia G et al (1990) Neuron 4(5) : 759-65.
    PubMedID: 2160838
  • Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease.

    Adeosun SO et al (2012) PLoS One 7(11) : e50040.
    PubMedID: 23209637

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