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Data

Product overview

  • Name
    AM 281
  • Short description
    Potent, selective CB1 receptor antagonist / inverse agonist
  • Biological description
    AM 281 is a potent, selective CB1 receptor antagonist / inverse agonist which is selective for CB1 over CB2 receptors (Ki values are 12 nM and 4200 nM respectively). AM 281 modulates locomotor activity and shows neuroprotective actions in septic shock.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-(2,4-Dichlorophenyl)-5-(4-iodophe nyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carbox amide
  • Molecular Weight
    557.22
  • Chemical structure
    AM 281
  • Molecular Formula
    C21H19Cl2IN4O2
  • CAS Number
    202463-68-1
  • PubChem identifier
    4302962
  • SMILES
    CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
  • Source
    Synthetic
  • InChi
    InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
  • InChiKey
    AJFFBPZYXRNAIC-UHFFFAOYSA-N
  • MDL number
    MFCD01861180
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (50 mM with heating)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AM 281

  • Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand.

    Lan et al (1999) AAPS PharmSci. 1(2) : E4
    PubMedID: 11741201
  • Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices.

    Gifford et al (1997) Neurosci Lett. 238(1-2) : 84-6
    PubMedID: 9464661
  • Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats.

    Kadoi et al (2005) Crit Care Med 33(11) : 2629-36
    PubMedID: 16276190
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