Product overview

  • Name
    AM 404
  • Short description
    Selective, competitive carrier-mediated anandamide transport inhibitor
  • Biological description
    Selective and competitive carrier-mediated anandamide transport inhibitor (IC50 = 1 µM). Activates vanilloid receptors. Shows vasodilator, neuroprotective and anxiolytic actions mediated by 5-HT1A receptors.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
  • Molecular Weight
    395.58
  • Chemical structure
    AM 404  [198022-70-7]
  • Molecular Formula
    C26H37NO2
  • CAS Number
    198022-70-7

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in ethanol (50mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AM 404

  • Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.

    Zani A et al (2007) Br J Pharmacol 152(8) : 1301-11.
    PubMedID: 17965746
  • 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.

    Braida D et al (2007) Eur J Pharmacol 555(2-3) : 156-63.
    PubMedID: 17116299
  • The anandamide transport inhibitor AM404 activates vanilloid receptors.

    Zygmunt PM et al (2000) Eur J Pharmacol 396(1) : 39-42.
    PubMedID: 10822052
  • Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.

    Giuffrida A et al (2001) J Pharmacol Exp Ther 298(1) : 7-14.
    PubMedID: 11408519

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