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Amantadine hydrochloride

(HB0109)
Data

Product overview

  • Name
    Amantadine hydrochloride
  • Short description
    Non-competitive NMDA receptor antagonist
  • Biological description
    Non-competitive NMDA receptor antagonist (IC50 = approx 35 µM). May also block serotonin uptake. Shows antiviral effects in vivo. Acts as a dopaminergic agent with anti-parkinsonian effects; suppresses L-DOPA-induced dyskinesia. Induces D2 and D3 receptor up-regulation. Blood-brain barrier permeable.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Adamantan-1-amine hydrochloride
  • Molecular Weight
    187.71
  • Chemical structure
    Amantadine  [665-66-7]
  • Molecular Formula
    C10H17N.HCl
  • CAS Number
    665-66-7
  • PubChem identifier
    64150
  • SMILES
    C1C2CC3CC1CC(C2)(C3)N.Cl
  • InChi
    InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
  • InChiKey
    WOLHOYHSEKDWQH-UHFFFAOYSA-N
  • MDL number
    MFCD00074723

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Amantadine hydrochloride

  • Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.

    Blanpied et al (2005) J Neurosci 25(13) : 3312-22
    PubMedID: 15800186
  • Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.

    Rogoz et al (2003) J Physiol Pharmacol. 54(2) : 257-70
    PubMedID: 12832726
  • Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.

    Jing et al (2008) Proc Natl Acad Sci U S A 105(31) : 10967-72
    PubMedID: 18669647
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