Product overview

Name Amastatin hydrochloride
Purity >98%
Description Competitive aminopeptidase (AP) inhibitor
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Biological Data

Biological description Slow, tight binding and competitive aminopeptidase (AP) inhibitor. Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase, human serum aminopeptidase A (AP-A), aminopeptidase N (AP-N), tyrosine aminopeptidase, but not of aminopeptidase B (AP-B). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme. Slightly inhibits the formation of angiotensin III (Ang III) from Ang II through AP-A, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. Moderate inhibitor of mitochondrial intermediate peptidase (MIP). Weak inhibitor of simian immunodeficiency virus protease (SIV-PR).

Solubility & Handling

Storage instructions +4°C
Solubility overview

Soluble in aqueous buffers, and in ethanol

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name [(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH Hydrochloride
Molecular Weight 511.1
Chemical structure Amastatin hydrochloride [100938-10-1] Chemical Structure
Molecular Formula C21H38N4O8.HCl
CAS Number 100938-10-1
SMILES [Cl-].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O.[H+]
InChiKey GBDUPCKQTDKNLS-PORDUOSCSA-N
Appearance White to off-white powder