AMD 3100 octahydrochloride

(HB2739)

Product overview

  • Name
    AMD 3100 octahydrochloride
  • Short description
    Potent, selective CXCR4 antagonist. Mobilizes hematopoietic stem cells.
  • Biological description
    Potent and selective CXCR4 antagonist (IC50 values are 0.79 and 0.18 at CXCR4 and CCR2 respectively). Blocks the route of HIV entry into T-cells. Shows potent anti-HIV activity in vitro and in vivo. Also mobilizes hematopoietic stem cells.
  • Alternative names
    Plerixafor | JM3100
  • Biological action
    Antagonist
  • Citations

Properties

  • Chemical name
    1,1'-[1,4-Phenylenebis-(methylene)]- bis-(1,4,8,11-tetraazacyclotetradecane) octahydrochloride
  • Molecular Weight
    794.48
  • Chemical structure
    AMD 3100 octahydrochloride | JM 3100, Plerixafor  [155148-31-5]
  • Molecular Formula
    C28H54N8.8HCl
  • CAS Number
    155148-31-5

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AMD 3100 octahydrochloride

  • Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.

    Bridger et al (1995) J Med Chem 38(2) : 366-78
    PubMedID: 7830280
  • Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4.

    Fricker et al (2006) Biochem Pharmacol 72(5) : 588-96
    PubMedID: 16815309
  • Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization defective CD26-/- mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis.

    Paganessi (2011) Exp Hematol 39(3) : 384-90
    PubMedID: 21168468