AMG 9810

(HB1188)

Product overview

  • Name
    AMG 9810
  • Short description
    Potent, selective, competitive TRPV1 channel antagonist
  • Biological description
    Potent, selective and competitive TRPV1 channel antagonist (IC50 values are 24.5 and 85.6 nM for human and rat TRPV1 respectively). Competitively inhibits capsaicin binding to rat TRPV1. Displays antihyperalgesic effects.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
  • Molecular Weight
    337.42
  • Chemical structure
    AMG 9810  [545395-94-6]
  • Molecular Formula
    C21H23NO3
  • CAS Number
    545395-94-6

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AMG 9810

  • AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.

    Gavva NR et al (2005) J Pharmacol Exp Ther 313(1) : 474-84.
    PubMedID: 15615864
  • Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis.

    Hu Y et al (2014) Am J Physiol Gastrointest Liver Physiol 307(2) : G149-57.
    PubMedID: 24875100
  • No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex.

    Liu MG et al (2014) Mol Brain 7 : 27
    PubMedID: 24708859

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