Amlodipine besylate
(HB1214)
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Amlodipine besylate
(HB1214)- Data
- Support & Resources
Data
Product overview
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Name
Amlodipine besylate
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Short description
L-type calcium channel blocker
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Biological description
L-type calcium channel blocker. Decreases eNOS expression in the aorta. Shows antiproliferative, antihypertensive, antioxidant, anti-inflammatory, vasoprotective and neuroprotective actions.
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Biological action
Blocker
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Purity
>99%
- Citations
Properties
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Chemical name
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
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Molecular Weight
567.05
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Chemical structure
![Amlodipine besylate [111470-99-6]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "Amlodipine besylate [111470-99-6]")
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Molecular Formula
C20H25ClN2O5.C6H6O3S
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CAS Number
111470-99-6
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PubChem identifier
60496
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SMILES
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
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InChi
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
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InChiKey
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
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MDL number
MFCD00887594
![Amlodipine besylate [111470-99-6]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb1214_2.png "Amlodipine besylate [111470-99-6]")
Storing and Using Your Product
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Storage instructions
Room temperature
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Solubility overview
Soluble in water (10mM) and in DMSO (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Amlodipine besylate
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Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.
Yoshida J et al (2003) Eur J Pharmacol 472(1-2) : 23-31.PubMedID: 12860469 -
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Toba H et al (2005) Hypertens Res 28(8) : 689-700.PubMedID: 16392774 -
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Toba H et al (2005) Hypertens Res 28(8) : 689-700.PubMedID: 16392774 -
Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells.
Choi NY et al (2014) Brain Res 1551 : 1-12.PubMedID: 24440775
Support & Resources
Reviews & Product Guides
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