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Amlodipine besylate

(HB1214)
Data

Product overview

  • Name
    Amlodipine besylate
  • Short description
    L-type calcium channel blocker
  • Biological description
    L-type calcium channel blocker. Decreases eNOS expression in the aorta. Shows antiproliferative, antihypertensive, antioxidant, anti-inflammatory, vasoprotective and neuroprotective actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
  • Molecular Weight
    567.05
  • Chemical structure
    Amlodipine besylate  [111470-99-6]
  • Molecular Formula
    C20H25ClN2O5.C6H6O3S
  • CAS Number
    111470-99-6
  • PubChem identifier
    60496
  • SMILES
    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
  • InChi
    InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
  • InChiKey
    ZPBWCRDSRKPIDG-UHFFFAOYSA-N
  • MDL number
    MFCD00887594

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (10mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Amlodipine besylate

  • Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.

    Yoshida J et al (2003) Eur J Pharmacol 472(1-2) : 23-31.
    PubMedID: 12860469
  • Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta

    Toba H et al (2005) Hypertens Res 28(8) : 689-700.
    PubMedID: 16392774
  • Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta

    Toba H et al (2005) Hypertens Res 28(8) : 689-700.
    PubMedID: 16392774
  • Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells.

    Choi NY et al (2014) Brain Res 1551 : 1-12.
    PubMedID: 24440775
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