Amlodipine besylate

(HB1214)

Pack	Price	Qty
50mg	$75

(HB1214)

Data

Product overview

Name
Amlodipine besylate
Short description
L-type calcium channel blocker
Biological description
L-type calcium channel blocker. Decreases eNOS expression in the aorta. Shows antiproliferative, antihypertensive, antioxidant, anti-inflammatory, vasoprotective and neuroprotective actions.
Biological action
Blocker
Purity
>99%
Citations
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Chemical name
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarbo xylic acid 3-ethyl 5-methyl ester benzenesulfonate
Molecular Weight
567.05
Chemical structure
Molecular Formula
C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
CAS Number
111470-99-6
PubChem identifier
60496
SMILES
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
InChi
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChiKey
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
MDL number
MFCD00887594

Storage instructions
Room temperature
Solubility overview
Soluble in water (10mM) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.
Yoshida J et al (2003) Eur J Pharmacol 472(1-2) : 23-31.
PubMedID: 12860469
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Toba H et al (2005) Hypertens Res 28(8) : 689-700.
PubMedID: 16392774
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Toba H et al (2005) Hypertens Res 28(8) : 689-700.
PubMedID: 16392774
Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells.
Choi NY et al (2014) Brain Res 1551 : 1-12.
PubMedID: 24440775

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