Anacardic acid
(HB1380)- Data
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Data
Product overview
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Name
Anacardic acid
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Short description
Non-competitive HAT inhibitor
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Biological description
Non-competitive histone acetyltransferase (HAT) inhibitor. Inhibits p300/CBP and p300-associated factor HAT actions (IC50 values are 5 and 8.5 µM respectively). Also inhibits NF-κB, induces ER stress and autophagy. Shows anti-cancer and anti-inflammatory actions.
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Alternative names
AA
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Biological action
Inhibitor
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Purity
>97%
- Citations
Properties
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Chemical name
2-Hydroxy-6-pentadecylbenzoic acid
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Molecular Weight
348.52
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Chemical structure
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Molecular Formula
C22H36O3
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CAS Number
16611-84-0
Storing and Using Your Product
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Storage instructions
-20°C
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Solubility overview
soluble in DMSO (100mM) or ethanol (50mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Anacardic acid
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Small molecule modulators of histone acetyltransferase p300.
Balasubramanyam K et al (2003) J Biol Chem 278(21) : 19134-40.PubMedID: 12624111 -
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the i
Sung B et al (2008) Blood 111(10) : 4880-91.PubMedID: 18349320 -
Induction of the endoplasmic reticulum stress and autophagy in human lung carcinoma A549 cells by anacardic acid.
Seong YA et al (2014) Cell Biochem Biophys 68(2) : 369-77.PubMedID: 23955513
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