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Angiotensin II (human)

(HB3488)
Data

Product overview

  • Name
    Angiotensin II (human)
  • Short description
    Endogenous peptide hormone. Potent vasoconstrictor.
  • Biological description

    Angiotensin II is a peptide endocrine hormone which is involved in a variety of biological processes.


    Angiotensin II is the primary effector of the RAS (renin-angiotensin system) which is a central component of the physiological/ pathophysiological responses of the cardiovascular system.

    Stimulation with angiotensin II modulates blood pressure and regulates vasoconstriction and salt/water homeostasis.

    Angiotensin II is also associated with induction of smooth muscle cell growth.

     


    Angiotensin II is also involved in the inflammatory process. It is considered a growth factor that regulates cell growth and fibrosis. It increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on various cell types (e.g. leucocytes, endothelial cells and vascular smooth muscle cells).

  • Alternative names
    AngII, Ang-II, Ang II
  • Biological action
    Activator
  • Citations

Properties

  • Chemical name
    DRVYIHPF
  • Molecular Weight
    1046.2
  • Chemical structure
    Angiotensin II (human) [4474-91-3]
  • Molecular Formula
    C50H71N13O12
  • Sequence (one letter)
    DRVYIHPF
  • Sequence (three letter)
    Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
  • CAS Number
    4474-91-3
  • PubChem identifier
    172198
  • SMILES
    CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
  • InChiKey
    CZGUSIXMZVURDU-JZXHSEFVSA-N
  • Protein length
    8

Storing and Using Your Product

  • Storage instructions
    Desiccate at -20°C
  • Solubility overview
    Soluble in water (1 mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Angiotensin II (human)

  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
    PubMedID: 20597104
  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
    PubMedID: 20597104
  • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

    Mehta et al (2007) Am J Physiol Cell Physiol 292(1) : 82-97
    PubMedID: 16870827
  • Inflammation and angiotensin II.

    Suzuki et al (2003) Int J Biochem Cell Biol 35(6) : 881-900
    PubMedID: 12676174
  • Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade.

    Dandona et al (2007) J Hum Hypertens. 21(1) : 20-7
    PubMedID: 17096009
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