Anisomycin

(HB2239)

Product overview

  • Name
    Anisomycin
  • Short description
    Protein synthesis inhibitor. Potent JNK / p38 MAPK activator.
  • Biological description

    Protein synthesis inhibitor which prevents elongation and causes polysome stabilization by binding to the 60S ribosomal subunit to prevent peptide bond formation.

    Also acts as a potent JNK and p38 MAPK activator.


    Initiates intracellular signals for rapid induction of immediate-early (IE) genes (e.g. c-fos, fosB, c-jun, JunB and JunD).


    Additionally, thought to block late long-term potentiation (L-LTP) and at high doses reduces neuronal activity.

  • Alternative names
    ANI | Flagecidin
  • Biological action
    Antibiotic
  • Our products in action

Properties

  • Chemical name
    (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
  • Molecular Weight
    265.31
  • Molecular Formula
    C14H19NO4
  • CAS Number
    22862-76-6
  • PubChem identifier
    253602
  • SMILES
    CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O
  • InChiKey
    YKJYKKNCCRKFSL-RDBSUJKOSA-N
  • MDL number
    MFCD00077650
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    +4 °C;
  • Solubility overview
    Soluble in ethanol (50 mM) and DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Anisomycin

  • Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.

    Hazzalin et al (1998) Mol Cell Biol. 18(4) : 1844-54.
    PubMedID: 9528756
  • The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.

    Croons et al (19286921) J Pharmacol Exp Ther 329(3) : 856-64
    PubMedID: 19286921
  • Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording.

    Mochida et al (2001) Neuroreport 12(5) : 987-91
    PubMedID: 11303774

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