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Biological Data

Biological description TRPA1 channel antagonist (IC50 values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
Molecular Weight 209.67
Chemical structure AP 18  [55224-94-7] Chemical Structure
Molecular Formula C11H12ClNO
CAS Number 55224-94-7
PubChem identifier 9584673
SMILES ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1
InChiKey MHTJEUOFLVQMCL-NJHPPEEMSA-N

References for AP 18

References are publications that support the biological activity of the product
  • Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

    Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.
  • Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

    Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.
  • A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

    Petrus M et al (2007) Mol Pain 3 : 40

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