AP 18
(HB1157)
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AP 18
(HB1157)- Data
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Data
Product overview
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Name
AP 18
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Short description
TRPA1 channel antagonist
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Biological description
TRPA1 channel antagonist (IC50 values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.
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Biological action
Antagonist
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Purity
>98%
- Citations
Properties
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Chemical name
4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
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Molecular Weight
209.67
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Chemical structure
![AP 18 [55224-94-7]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "AP 18 [55224-94-7]")
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Molecular Formula
C11H12ClNO
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CAS Number
55224-94-7
![AP 18 [55224-94-7]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb1157.png "AP 18 [55224-94-7]")
Storing and Using Your Product
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Storage instructions
+4°C
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Solubility overview
soluble in DMSO (100mM) or ethanol (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for AP 18
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A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.
Petrus M et al (2007) Mol Pain 3 : 40PubMedID: 18086313 -
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.
Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.PubMedID: 19171673 -
Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.
Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.PubMedID: 19945872
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