AP 18

(HB1157)

Order: HB1157

Pack	Price	Qty
25mg	$234

(HB1157)

Data

Product overview

Name
AP 18
Short description
TRPA1 channel antagonist
Biological description
TRPA1 channel antagonist (IC₅₀ values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.
Biological action
Antagonist
Purity
>98%
Citations
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Storage instructions
+4°C
Solubility overview
soluble in DMSO (100mM) or ethanol (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

Petrus M et al (2007) Mol Pain 3 : 40
PubMedID: 18086313
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.
PubMedID: 19171673
Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.
PubMedID: 19945872

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