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Product overview

  • Name
    AP 18
  • Short description
    TRPA1 channel antagonist
  • Biological description
    TRPA1 channel antagonist (IC50 values are 3.1 and 4.5 µM for human TRPA1 and rat TRPA1 respectively). Exhibits little or no activity for TRPV1 - TRPV4 channels. Reduces cinnameldehyde-induced nociception but not capsaicin-induced nociception. Also partially reverses cold hyperalgesia.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
  • Molecular Weight
  • Chemical structure
    AP 18  [55224-94-7]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AP 18

  • A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

    Petrus M et al (2007) Mol Pain 3 : 40
    PubMedID: 18086313
  • Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

    Taylor-Clark TE et al (2009) Mol Pharmacol 75(4) : 820-9.
    PubMedID: 19171673
  • Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor.

    Defalco J et al (2010) Bioorg Med Chem Lett 20(1) : 276-9.
    PubMedID: 19945872
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