Apamin

(HB1051)

Product overview

  • Name
    Apamin
  • Short description
    Potent, selective KCa2 channel subfamily inhibitor
  • Biological description
    Potent, selective KCa2 channel subfamily inhibitor (IC50 values are 3.3 nM and 83 pM for hKCa2.1 and rKCa2.2 channels respectively). Found in the venom of Apis mellifera bee. Blood brain barrier permeable. Displays anti-inflammatory properties.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Molecular Weight
    2027.34
  • Molecular Formula
    C79H131N31O24S4
  • CAS Number
    24345-16-2

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in water (1mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Apamin

  • Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.

    Strøbaek D et al (2000) Br J Pharmacol 129(5) : 991-9.
    PubMedID: 10696100
  • Behavioral effects of apamin, a selective inhibitor of the SK(Ca)-channel, in mice and rats.

    van der Staay FJ et al (1999) Neurosci Biobehav Rev 23(8) : 1087-110.
    PubMedID: 10643819
  • The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice.

    Kim SJ et al (2012) Evid Based Complement Alternat Med 2012 : 305454
    PubMedID: 22645626
  • Apamin.

    Habermann E (1984) Pharmacol Ther 25(2) : 255-70.
    PubMedID: 6095335

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