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(+)-Aphidicolin

(HB3690)
Data

Product overview

  • Name
    (+)-Aphidicolin
  • Short description
    DNA polymerase α and δ inhibitor
  • Biological description
    Antibiotic. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol
  • Molecular Weight
    338.5
  • Chemical structure
    (+)-Aphidicolin [38966-21-1]
  • Molecular Formula
    C20H34O4
  • CAS Number
    38966-21-1
  • PubChem identifier
    457964
  • InChiKey
    NOFOAYPPHIUXJR-APNQCZIXSA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in Dimethylsulfoxide
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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