Apoptosis Activator 2

(HB1293)

Product overview

  • Name
    Apoptosis Activator 2
  • Short description
    Caspase activator
  • Biological description
    Cytochrome C-dependent caspase activator. Increases Apaf-1 oligomerization forming apoptosomes. Activates caspase-3 following caspase-9 activation. Induces PARP cleavage and DNA fragmentation. Shows apoptotic and anti-cancer actions.
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
  • Molecular Weight
    306.14
  • Molecular Formula
    C15H9Cl2NO2
  • CAS Number
    79183-19-0

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (5mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Apoptosis Activator 2

  • Direct activation of the apoptosis machinery as a mechanism to target cancer cells.

    Nguyen JT et al (2003) Proc Natl Acad Sci U S A 100(13) : 7533-8.
    PubMedID: 12808146
  • Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody.

    Farivar TN et al (2012) N Am J Med Sci 4(11) : 582-5.
    PubMedID: 23181231
  • Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.

    Alavian KN et al (2009) Neural Dev 4 : 11
    PubMedID: 19291307

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