AR-A 014418

(HB1258)

Product overview

  • Name
    AR-A 014418
  • Short description
    Potent, selective GSK3 inhibitor
  • Biological description
    Potent and selective GSK3 inhibitor (IC50 = 104 nM) which acts competitively. Exhibits little activity for cdk2 and cdk5 (IC50 values are >100 µM). Also inhibits tau phosphorylation (IC50 = 2.7 µM).
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
  • Molecular Weight
    308.31
  • Chemical structure
    AR-A 014418  [487021-52-3]
  • Molecular Formula
    C12H12N4O4S
  • CAS Number
    487021-52-3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (5mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for AR-A 014418

  • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.

    Bhat R et al (2003) J Biol Chem 278(46) : 45937-45.
    PubMedID: 12928438
  • AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.

    Yadav AK et al (2014) J Oncol 2014 : 695325
    PubMedID: 24550987

Reviews & Product Guides