AR-A 014418
(HB1258)
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AR-A 014418
(HB1258)- Data
- Support & Resources
Data
Product overview
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Name
AR-A 014418
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Short description
Potent, selective GSK3 inhibitor
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Biological description
Potent and selective GSK3 inhibitor (IC50 = 104 nM) which acts competitively. Exhibits little activity for cdk2 and cdk5 (IC50 values are >100 µM). Also inhibits tau phosphorylation (IC50 = 2.7 µM).
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Biological action
Inhibitor
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Purity
>99%
- Citations
Properties
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Chemical name
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
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Molecular Weight
308.31
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Chemical structure
![AR-A 014418 [487021-52-3]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "AR-A 014418 [487021-52-3]")
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Molecular Formula
C12H12N4O4S
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CAS Number
487021-52-3
![AR-A 014418 [487021-52-3]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb1258.png "AR-A 014418 [487021-52-3]")
Storing and Using Your Product
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Storage instructions
+4°C
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Solubility overview
soluble in DMSO (100mM) or ethanol (5mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for AR-A 014418
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Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Bhat R et al (2003) J Biol Chem 278(46) : 45937-45.PubMedID: 12928438 -
AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Yadav AK et al (2014) J Oncol 2014 : 695325PubMedID: 24550987
Support & Resources
Reviews & Product Guides
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