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Arcaine sulfate


Product overview

  • Name
    Arcaine sulfate
  • Short description
    Competitive NMDA receptor antagonist / NOS inhibitor
  • Biological description
    Competitive NMDA receptor antagonist. Binds at the polyamine site. Also a NOS (Nitric oxide synthase) inhibitor. Reduces NMDA single-channel currents in a voltage-dependent manner.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    N,N'-1,4-Butanediylbisguanidine sulfate
  • Molecular Weight
  • Chemical structure
    Arcaine sulfate  [14923-17-2]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Arcaine sulfate

  • Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain.

    Yokoi I et al (1994) Neuropharmacology 33(11) : 1261-5.
    PubMedID: 7532812
  • Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.

    Reynolds IJ (1990) Eur J Pharmacol 177(3) : 215-6.
    PubMedID: 2155812
  • Investigation of the actions and antagonist activity of some polyamine analogues in vivo.

    Doyle KM et al (1998) Br J Pharmacol 124(2) : 386-90.
    PubMedID: 9641557
  • Spermine and arcaine block and permeate N-methyl-D-aspartate receptor channels.

    Araneda RC et al (1999) Biophys J 76(6) : 2899-911.
    PubMedID: 10354418
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