Arctigenin

(HB0119)

Product overview

  • Name
    Arctigenin
  • Short description
    Potent MAP kinase kinase (MKK/MEK) inhibitor
  • Biological description
    Potent MAP kinase kinase (MKK/MEK) inhibitor (IC50 = 1 nM for MKK1/MEK1). Antiviral, anti-cancer, antioxidant and anti-inflammatory compound. Inhibits iNOS expression by suppressing 1-κBα phosphorylation and nuclear translocation of p65 (IC50 = 10 nM). Shows neuroprotective actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
  • Molecular Weight
    372.42
  • Chemical structure
    Arctigenin  [7770-78-7]
  • Molecular Formula
    C21H24O6
  • CAS Number
    7770-78-7

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in ethanol (25mM, gentle warming) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Arctigenin

  • Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.

    Jang YP et al (2002) J Neurosci Res 68(2) : 233-40.
    PubMedID: 11948668
  • Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.

    Cho MK et al (2002) Int Immunopharmacol 2(1) : 105-16.
    PubMedID: 11789661
  • Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.

    Yang S et al (2012) Anat Rec (Hoboken) 295(8) : 1260-6.
    PubMedID: 22619087
  • Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.

    Cho MK et al (2004) 4(10-11) : 1419-29
    PubMedID: 15313439