Ascomycin

(HB0123)

Product overview

  • Name
    Ascomycin
  • Short description
    Calcineurin phosphatase inhibitor
  • Biological description
    Calcineurin phosphatase inhibitor that binds to FK 506-binding protein 12 (FKBP12) (IC50 = 49 nM). Also suppresses T-cells (IC50 = 3.9 nM). Displays neurogenerative, neuroprotective and anticonvulsant properties.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R ,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E )-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth yl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
  • Molecular Weight
    792.01
  • Chemical structure
    Ascomycin  [104987-12-4]
  • Molecular Formula
    C43H69NO12
  • CAS Number
    104987-12-4

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ascomycin

  • Genetically engineered analogs of ascomycin for nerve regeneration.

    Revill WP et al (2002) J Pharmacol Exp Ther 302(3) : 1278-85.
    PubMedID: 12183690
  • Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.

    Sierra-Paredes G et al (2008) CNS Neurosci Ther 14(1) : 36-46.
    PubMedID: 18482098
  • Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.

    Vázquez-López A et al (2006) Pharmacol Biochem Behav 84(3) : 511-6.
    PubMedID: 16872668

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