Azidothymidine

(HB4602)

Product overview

  • Name
    Azidothymidine
  • Short description
    Selective reverse transcriptase inhibitor with anti-HIV activity. Decreases CRISPR-mediated homology directed repair (HDR) and enhances gene knockout efficiency.
  • Biological description
    Selective reverse transcriptase inhibitor which exhibits 100-fold selectivity for HIV reverse transcriptase compared to DNA polymerase α. Blocks HIV replication and exhibits anti-HIV activity. Orally bioavailable and brain penetrant. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency and enhances gene knockout efficiency.
  • Alternative names
    AZT, ZDV
  • Our products in action

Properties

  • Chemical name
    3'-Azido-3'-deoxythymidine
  • Molecular Weight
    267.2
  • Chemical structure
    Azidothymidine [30516-87-1]
  • Molecular Formula
    C10H13N5O4
  • CAS Number
    30516-87-1
  • PubChem identifier
    5726
  • SMILES
    CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
  • InChi
    InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)
  • InChiKey
    HBOMLICNUCNMMY-UHFFFAOYSA-N
  • MDL number
    MFCD00006536
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (50 mM) and in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Azidothymidine

  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

    Mitsuya et al (1985) Proc Natl Acad Sci U S A 82(20) : 7096-100
    PubMedID: 2413459
  • The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.

    Broder (2010) Antiviral Res 85(1) : 1-18
    PubMedID: 20018391
  • Small molecules enhance CRISPR genome editing in pluripotent stem cells.

    Yu et al (2015) Cell Stem Cell 16(2) : 142-7
    PubMedID: 25658371