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Product overview

  • Name
    Bafilomycin A1
  • Short description
    Highly potent, selective V-ATPase inhibitor. Autophagy inhibitor.
  • Biological description
    Highly potent and selective vacuolar-type proton translocating ATPase (V-ATPase) inhibitor (IC50 = 50 pM for chromaffin granule membranes). Inhibits autophagy by targeting lysosomes. Displays neuroprotective, pro-apoptotic and antibiotic properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey
  • MDL number
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20 °C
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Handling
    Avoid freeze-thaw cycles. Aliquots of stock solutions should only be thawed once, immediately before use
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bafilomycin A1

  • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.

    Yamamoto A et al (1998) Cell Struct Funct 23(1) : 33-42.
    PubMedID: 9639028
  • Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.

    Shacka JJ et al (2006) Mol Pharmacol 69(4) : 1125-36.
    PubMedID: 16391239
  • Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

    Bowman EJ et al (1988) Proc Natl Acad Sci U S A 85(21) : 7972-6.
    PubMedID: 2973058
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Reviews & Product Guides


  • Verified customer,

    Does what it should. The product works as intended and is a good tool for monitoring autophagic flux.