Bafilomycin A1

(HB1125)

Product overview

  • Name
    Bafilomycin A1
  • Short description
    Highly potent, selective V-ATPase inhibitor
  • Biological description
    Highly potent and selective vacuolar-type proton translocating ATPase (V-ATPase) inhibitor (IC50 = 50 pM for chromaffin granule membranes). Displays neuroprotective, pro-apoptotic and antibiotic properties.
  • Biological action
    Antibiotic
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
  • Molecular Weight
    622.84
  • Molecular Formula
    C35H58O9
  • CAS Number
    88899-55-2
  • PubChem identifier
    6436223
  • SMILES
    C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
  • InChiKey
    XDHNQDDQEHDUTM-JQWOJBOSSA-N
  • MDL number
    MFCD06795130
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20 °C;
  • Solubility overview
    Soluble in DMSO (100 mM)

References for Bafilomycin A1

  • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.

    Yamamoto A et al (1998) Cell Struct Funct 23(1) : 33-42.
    PubMedID: 9639028
  • Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.

    Shacka JJ et al (2006) Mol Pharmacol 69(4) : 1125-36.
    PubMedID: 16391239
  • Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

    Bowman EJ et al (1988) Proc Natl Acad Sci U S A 85(21) : 7972-6.
    PubMedID: 2973058

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