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Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (1 mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical structure | ![BAM (8-22) [412961-36-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "BAM (8-22) [412961-36-5]") |
| Molecular Formula | C91H127N25O23S |
| Sequence (one letter) | VGRPEWWMDYQKRYG |
| Sequence (three letter) | Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly |
| PubChem identifier | 16158367 |
| SMILES | CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)NCC(=O)O)N |
| InChiKey | GOEYECACIBFJGZ-NPAGUKBMSA-N |
References for BAM (8-22)
References are publications that support the biological activity of the product
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Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
Li et al (2017) Proc Natl Acad Sci U S A. 114(10) : E1996-E2005 -
BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.
Sikand et al (2011) J Neurosci 31(20) : 7563-7 -
Mas-related G-protein-coupled receptors inhibit pathological pain in mice.
Guan et al (2010) Proc Natl Acad Sci U S A. 107(36) : 15933-8
Publications
These publications cite the use of BAM (8-22) purchased from Hello Bio:
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Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
McMillan H et al (2021) FASEB J 35(5) : e21492
Product of proenkephalin A. MRGPRs activator.
![BAM (8-22) [412961-36-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2922_1.png "BAM (8-22) [412961-36-5]")
Understanding purity and quality - a guide for life scientists
