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Data

Product overview

  • Name
    BAM (8-22)
  • Short description
    Product of proenkephalin A. MRGPRs activator.
  • Biological description

    BAM (8-22) is a product of the opioid precursor proenkephalin A. It is a potent activator of Mas-related GPCR (MRGPRs): MRGPRC C11 and hMRGPRX1.


    BAM (8-22) does not contain the met-enekphalin motif (unlike BAM-22P) and therefore lacks affinity for opioid receptors.


    Active in vivo. Produces itch and nociceptive sensations.

  • Biological action
    Activator
  • Citations

Properties

  • Molecular Weight
    1971.22
  • Chemical structure
    BAM (8-22) [412961-36-5]
  • Molecular Formula
    C91H127N25O23S
  • Sequence (one letter)
    VGRPEWWMDYQKRYG
  • Sequence (three letter)
    Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly
  • CAS Number
    412961-36-5
  • PubChem identifier
    16158367
  • SMILES
    CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)NCC(=O)O)N
  • InChiKey
    GOEYECACIBFJGZ-NPAGUKBMSA-N
  • Protein length
    15

Storing and Using Your Product

  • Storage instructions
    Desiccate at -20°C
  • Solubility overview
    Soluble in water (1 mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for BAM (8-22)

  • BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

    Sikand et al (2011) J Neurosci 31(20) : 7563-7
    PubMedID: 21593341
  • Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.

    Li et al (2017) Proc Natl Acad Sci U S A. 114(10) : E1996-E2005
    PubMedID: 28223516
  • Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

    Guan et al (2010) Proc Natl Acad Sci U S A. 107(36) : 15933-8
    PubMedID: 20724664
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