BAPTA-AM

(HB0981)

Product overview

  • Name
    BAPTA-AM
  • Short description
    Cell permeable Ca2+ chelator
  • Biological description
    Cell permeable Ca2+ chelator. Hydrolysed by cytosolic esterases. Useful for manipulation of cellular Ca2+ levels. Open channel blocker of Kv channels (IC50 values are 1.3, 1.45 and 1.23 µM for Kv 11.1, hKv 1.3 and hKv 1.5 channels respectively). BAPTA analog.
  • Biological action
    Chelator
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    1,2-Bis(2-aminophenoxy)ethane-N,N,N ',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
  • Molecular Weight
    764.68
  • Chemical structure
    BAPTA-AM  [126150-97-8]
  • Molecular Formula
    C34H40N2O18
  • CAS Number
    126150-97-8

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (30mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BAPTA-AM

  • The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells.

    Tang Q et al (2007) Biochem Pharmacol 74(11) : 1596-607.
    PubMedID: 17826747
  • Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.

    Chi Y et al (2011) J Pharmacol Exp Ther 339(1) : 257-66.
    PubMedID: 21765041
  • BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

    Wie MB et al (2001) Prog Neuropsychopharmacol Biol Psychiatry 25(8) : 1641-59.
    PubMedID: 11642660

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