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(±)-Bay K 8644


Product overview

  • Name
    (±)-Bay K 8644
  • Short description
    L-type Ca2+ channel agonist. Aids iPSCs generation from Mouse embryonic fibroblasts.
  • Biological description
    L-type Ca2+ channel agonist. Causes reduced inotropy in the myocardium. Also aids induced pluripotent stem cell generation from mouse embryonic fibroblasts (MEFs). Shows convulsive and vasoconstrictive actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
  • Molecular Weight
  • Chemical structure
    (±)-Bay K 8644  [71145-03-4]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (±)-Bay K 8644

  • Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.

    Chen X et al (2008) Am J Physiol Heart Circ Physiol 294(5) : H2257-67.
    PubMedID: 18359894
  • Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells.

    Sen N et al (1997) Biochem Pharmacol 53(9) : 1307-13.
    PubMedID: 9214691
  • Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice.

    Shin EJ et al (2004) Behav Brain Res 151(1-2) : 267-76.
    PubMedID: 15084442
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