BCTC

(HB1190)

Product overview

  • Name
    BCTC
  • Short description
    Potent, selective TRPV1 channel antagonist
  • Biological description
    Potent and selective TRPV1 channel antagonist (IC50 values are 6.0 and 35 nM for acid- and capsaicin-induced TRPV1 channels respectively). Also potent TRPM8 channel antagonist (IC50 = 143 nM). Blood brain barrier permeable. Displays analgesic properties.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
  • Molecular Weight
    372.89
  • Chemical structure
    BCTC  [393514-24-4]
  • Molecular Formula
    C20H25ClN4O
  • CAS Number
    393514-24-4
  • PubChem identifier
    9929425
  • SMILES
    CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
  • InChi
    InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
  • InChiKey
    ROGUAPYLUCHQGK-UHFFFAOYSA-N
  • MDL number
    MFCD08690556

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (40mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BCTC

  • Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.

    Benko R et al (2012) Eur J Pharmacol 674(1) : 44-50.
    PubMedID: 22056835
  • N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

    Valenzano KJ et al (2003) J Pharmacol Exp Ther 306(1) : 377-86.
    PubMedID: 12721338
  • N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath

    Pomonis JD et al (2003) J Pharmacol Exp Ther 306(1) : 387-93.
    PubMedID: 12721336
  • Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.

    Weil A et al (2005) Mol Pharmacol 68(2) : 518-27.
    PubMedID: 15911692

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