Benidipine hydrochloride

(HB1216)

Product overview

  • Name
    Benidipine hydrochloride
  • Short description
    Ca2+ channel inhibitor
  • Biological description
    L-, N- and T-type Ca2+ channel inhibitor (IC50 = 2.7 nM for ICa inhibition). Inhibits the activation of aldosterone-induced mineralocorticoid receptor. Shows anti-atherosclerotic, antihypertensive and cardioprotective actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (4R)-rel-1,4-Dihydro-2,6-dimethyl-4 -(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
  • Molecular Weight
    542.02
  • Chemical structure
    Benidipine hydrochloride  [91599-74-5]
  • Molecular Formula
    C28H31N3O6.HCl
  • CAS Number
    91599-74-5

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (75mM) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Benidipine hydrochloride

  • Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells.

    Yamamoto M et al (1990) Br J Pharmacol 100(4) : 669-76.
    PubMedID: 2169935
  • Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker.

    Yao K et al (2006) J Pharmacol Sci 100(4) : 243-61.
    PubMedID: 16565579
  • The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.

    Kosaka H et al (2010) Eur J Pharmacol 635(1-3) : 49-55.
    PubMedID: 20307534

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