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Product overview

  • Name
  • Short description
    Potent, selective mGlu2 positive allosteric modulator
  • Biological description
    Potent and selective mGlu2 receptor positive allosteric modulator (EC50 = 33.2 nM). Shows anxiolytic, antipsychotic effects and decreases drug addiction behaviors in rats.
  • Alternative names
    Biphenyl-indanone A; LS-193,571
  • Biological action
  • Purity
  • Customer comments

    Your BINA behaved as expected. Verified customer, Monash University

  • Citations



  • Chemical name
    3'-[[(2-Cyclopentyl-2,3-dihydro-6,7- dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
  • Molecular Weight
  • Chemical structure
    BINA  [866823-73-6]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BINA

  • Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

    Galici R et al (2006) J Pharmacol Exp Ther 318(1) : 173-85.
    PubMedID: 16608916
  • A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

    Benneyworth MA et al (2007) Mol Pharmacol 72(2) : 477-84.
    PubMedID: 17526600
  • The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

    Jin X et al (2010) Neuropsychopharmacology 35(10) : 2021-36.
    PubMedID: 20555310
Our products in action
The following papers have cited the use of BINA (HB0133) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • "Selective" Class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

    Hellyer et al (2018) Molecular Pharmacology DOI: : mol.117.111518
Support & Resources


  • Verified customer, Monash University

    Your BINA behaved as expected