BINA

(HB0133)

Product overview

  • Name
    BINA
  • Short description
    Potent, selective mGlu2 positive allosteric modulator
  • Biological description
    Potent and selective mGlu2 receptor positive allosteric modulator (EC50 = 33.2 nM). Shows anxiolytic, antipsychotic effects and decreases drug addiction behaviors in rats.
  • Alternative names
    Biphenyl-indanone A; LS-193,571
  • Biological action
    PAM
  • Purity
    >98%
  • Customer comments

    Your BINA behaved as expected. Verified customer, Monash University

  • Citations

Images

Properties

  • Chemical name
    3'-[[(2-Cyclopentyl-2,3-dihydro-6,7- dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
  • Molecular Weight
    454.56
  • Chemical structure
    BINA  [866823-73-6]
  • Molecular Formula
    C30H30O4
  • CAS Number
    866823-73-6
  • PubChem identifier
    9868580
  • SMILES
    CC1=C(C=C2CC(C(=O)C2=C1C)C3CCCC3)OCC4=CC=CC(=C4)C5=CC=C(C=C5)C(=O)O
  • InChi
    InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33)
  • InChiKey
    KMKBEESNZAPKMP-UHFFFAOYSA-N
  • MDL number
    MFCD19440914

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BINA

  • Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.

    Galici R et al (2006) J Pharmacol Exp Ther 318(1) : 173-85.
    PubMedID: 16608916
  • A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.

    Benneyworth MA et al (2007) Mol Pharmacol 72(2) : 477-84.
    PubMedID: 17526600
  • The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

    Jin X et al (2010) Neuropsychopharmacology 35(10) : 2021-36.
    PubMedID: 20555310

Reviews

  • Verified customer, Monash University

    Your BINA behaved as expected