Product overview

  • Name
    BIO
  • Short description
    Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.
  • Biological description
    Potent GSK-3α/β inhibitor (IC50 = 5 nM). Exhibits reduced activity at CDK1/cyclin B, CDK2/cyclinA, CDK4/cyclin D1, CDK5/p35, MAPKK andPKC-subunit α (IC50 values are 0.32, 0.30, 10, 0.08, 10 and 12 μM respectively). Induces β-catenin stabilisation and protects hippocampal neurons from Aβ oligomer damage. Also inhibits Tyr276/216 phosphorylation and reduces β-catenin phosphorylation. Cell permeable. Maintains embryonic stem cell self-renewal and pluripotency and displays proliferation enhancing properties.
  • Alternative names
    6-BIO; 6BIO
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (2'Z,3'E)-6-Bromoindirubin-3'-oxime
  • Molecular Weight
    356.17
  • Chemical structure
    BIO  [667463-62-9]
  • Molecular Formula
    C16H10BrN3O2
  • CAS Number
    667463-62-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (10mM) or ethanol (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BIO

  • Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics.

    Silva-Alvarez C et al (2013) Front Cell Neurosci 7 : 97
    PubMedID: 23805073
  • GSK-3-selective inhibitors derived from Tyrian purple indirubins.

    Meijer L et al (2003) Chem Biol 10(12) : 1255-66.
    PubMedID: 14700633
  • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes.

    Tseng AS et al (2006) Chem Biol 13(9) : 957-63.
    PubMedID: 16984885