Bisindolylmaleimide III

(HB0136)

Product overview

  • Name
    Bisindolylmaleimide III
  • Short description
    Selective PKC inhibitor
  • Biological description
    Selective protein kinase C (PKC) inhibitor. Competitive NQO2 inhibitor (Ki = 16.5 µM) and Ste20-related kinase (SLK) inhibitor (IC50 = 170 nM). Shows inhibitory action at PKCα, MSK1, MAPKAP-K1β, S6K1 and AMPK. Also CDK2 inhibitor (IC50 = 2 µM).
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    BIM III
  • Molecular Weight
    384.43
  • Chemical structure
    Bisindolylmaleimide III [137592-43-9]
  • Molecular Formula
    C23H20N4O2
  • CAS Number
    137592-43-9
  • PubChem identifier
    2398
  • SMILES
    C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN

Storing and Using Your Product

  • Solubility overview
    soluble in methanol or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bisindolylmaleimide III

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    PubMedID: 10998351
  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

    Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.
    PubMedID: 14769951
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    PubMedID: 1874734

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