Bisindolylmaleimide IV

(HB0137)

Product overview

  • Name
    Bisindolylmaleimide IV
  • Short description
    Selective, non-competitive PKC / PKA inhibitor
  • Biological description
    Selective and non-competitive protein kinase C (PKC) inhibitor (IC50 = 0.1 µM). Also inhibits protein kinase A (PKA) (IC50 = 2.0 µM). Blocks PLC/PKC signalling to block melatonin-induced potentiation of glycine currents in the retina.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Arcyriarubin A
  • Molecular Weight
    327.34
  • Chemical structure
    Bisindolylmaleimide IV  [119139-23-0]
  • Molecular Formula
    C20H13N3O2
  • CAS Number
    119139-23-0
  • PubChem identifier
    2399
  • SMILES
    C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

Storing and Using Your Product

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bisindolylmaleimide IV

  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.

    Davis PD et al (1992) J Med Chem 35(1) : 177-84.
    PubMedID: 1732526
  • Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

    Gould CM et al (2011) J Biol Chem 286(33) : 28922-30.
    PubMedID: 21715334
  • Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.

    Kline LW et al (2004) J Cardiovasc Pharmacol 43(2) : 281-7.
    PubMedID: 14716218
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    PubMedID: 1874734

Reviews & Product Guides