Bisindolylmaleimide V

(HB0138)

Product overview

  • Name
    Bisindolylmaleimide V
  • Short description
    Selective PKC / S6K inhibitor
  • Biological description
    Selective protein kinase C (PKC) inhibitor. Displays low affinity for muscarinic 1 receptor (Kd = 100 µM). Also mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) inhibitor (IC50 = 8.0 µM). Displays cytoprotective effects
  • Biological action
    Inhibitor
  • Citations

Properties

  • Molecular Weight
    341.3
  • Chemical structure
    Bisindolylmaleimide V  [113963-68-1]
  • Molecular Formula
    C21H15N3O2
  • CAS Number
    113963-68-1

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or methanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bisindolylmaleimide V

  • Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons.

    Asakai R et al (2002) Neurosci Res 44(3) : 297-304.
    PubMedID: 12413658
  • Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.

    Marmy-Conus N et al (2002) FEBS Lett 519(1-3) : 135-40.
    PubMedID: 12023032
  • Muscarinic interactions of bisindolylmaleimide analogues.

    Lazareno S et al (1998) Eur J Pharmacol 360(2-3) : 281-4.
    PubMedID: 9851596
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    PubMedID: 1874734

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