Bisindolylmaleimide VIII

(HB0141)

Product overview

  • Name
    Bisindolylmaleimide VIII
  • Short description
    Potent, selective PKC inhibitor
  • Biological description
    Potent and selective protein kinase C inhibitor (IC50 = 158 nM). Displays selectivity for PKC-α over PKC-β1, PKC-βII, PKC-γ and PKC-ε (IC50 values are 53, 195, 163, 213, 175 nM respectively). Facilitates Fas-mediated apoptosis and enhances DR5 mediated apoptosis. Also CDK2 antagonist (IC50 = 600 nM).
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Ro 31-7549 acetate
  • Molecular Weight
    458.6
  • Chemical structure
    Bisindolylmaleimide VIII [138516-31-1]
  • Molecular Formula
    C24H22N4O2.C2H4O2
  • CAS Number
    138516-31-1
  • PubChem identifier
    9868770
  • SMILES
    CC(=O)O.CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bisindolylmaleimide VIII

  • Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

    Zhou T et al (1999) Nat Med 5(1) : 42-8.
    PubMedID: 9883838
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.
    PubMedID: 8373348
  • Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.

    Ohtsuka T et al (2002) J Biol Chem 277(32) : 29294-303.
    PubMedID: 12034736
  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

    Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.
    PubMedID: 14769951

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