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Stability of DREADD Ligands in Solution - a Review

Stability of DREADD Ligands in Solution - a Review
By Sam Roome 1 years ago 1375 Views 1 comment

An exciting new field, DREADDs are engineered to be activated by synthetic small molecules (designer drugs) such as Clozapine N-Oxide (CNO). Until very recently, CNO (freebase) was the most widely used compound to activate the excitatory hM3Dq DREADD and the inhibitory hM4Di DREADD. However, new tools are emerging that offer alternatives to CNO – and that offer advantages in terms of ease of use, solubility, stability and metabolism.

Hello Bio offers a wide and unique range of water-soluble DREADDs ligands. These include:

  • Clozapine N-oxide dihydrochloride
  • Clozapine dihydrochloride
  • Perlapine dihydrochloride
  • Compound 21 (DREADD agonist 21) dihydrochloride (water soluble)

  • Many of these tools are novel, and as such, our expert chemists have carried out detailed stability and solubility testing to assess them. The data can help researchers make an informed decision regarding which ligand to choose for their particular assay or experiment.

    This technical review aims to answer common questions on how to handle, store and use the water-soluble DREADD ligands clozapine N-oxide dihydrochloride, clozapine dihydrochloride, perlapine dihydrochloride, and compound 21 (DREADD agonist 21) dihydrochloride (water soluble) for optimal results, and includes brand new data from stability and solubility studies.

    Read the review now

    Tom 1 years ago at 13:33
    This is great - really helpful