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Posts tagged 'DREADDs'

Novel water-soluble, potent DREADD ligands, licensed from the NIH

By Sam Roome 1 years ago 23988 Views No comments

We are delighted to announce that we have launched two novel water-soluble hM3Dq & hM4Di ligands – JHU37160 dihydrochloride and JHU37152 dihydrochloride. These are exciting tools for scientists studying GPCR and DREADD signalling. Hello Bio has been granted a licence from the National Institutes of Health to manufacture these novel tools and make them commercially available for the first time to life scientists worldwide. Find out more...

Stability of DREADD Ligands in Solution - a Review

By Sam Roome 1 years ago 1379 Views 1 comment

Check out our new technical review: Stability of DREADD ligands in solution. Find out all you need to know about how to handle, store and use commonly used water-soluble DREADD ligands (such as Clozapine N-oxide dihydrochloride, and Compound 21 dihydrochloride) - and discover brand new data on the stability of these important tools.

Water soluble DREADD ligands: only available from Hello Bio

By Sam Roome 2 years ago 2147 Views No comments

DREADDs are an increasingly popular field, but the pharmacological tools and ligands available have not been readily water soluble. Researchers have had to use DMSO or ethanol to solubilise them - which is not ideal for studies in biological systems. Our team of chemists have been hard at work to manufacture a range of DREADD ligands that are water soluble - many of which are only available from Hello Bio. They've been reviewed and rated by researchers too - find out more...

Water soluble clozapine: an exclusive from Hello Bio

By Sam Roome 2 years ago 2803 Views No comments

World exclusive! We are delighted to bring a novel water-soluble form of clozapine to researchers...

Perlapine hydrochloride - an exclusive new DREADD ligand

By Sam Roome 2 years ago 92057 Views No comments

Introducing perlapine hydrochloride (water soluble) - a new DREADD agonist, exclusive to Hello Bio!

An alternative to CNO? Water soluble Compound 21 (DREADD agonist 21)

By Sam Roome 2 years ago 208295 Views 1 comment

Do you work with DREADDs? If so you may be interested in our exciting new product launch - a possible alternative to clozapine N-oxide (water-soluble)...

Clozapine N-oxide (water soluble) - all your questions answered!

By Sam Roome 2 years ago 202493 Views 1 comment

How long does clozapine N-oxide stay stable in solution? What is the best way to solublise it? Is it light sensitive? Our chemists have been hard at work - carrying out detailed investigations into the solubility and stability of Clozapine N-oxide (water soluble). The result is worth reading - an exclusive technical review on Clozapine N-oxide (water soluble). It aims to answer all your questions on solubility, storage and handling, including results from our in-house tests, and guidelines on use in the lab...