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Why We Need to Make Biomedical Research More Open

Why We Need to Make Biomedical Research More Open
By Bronwen Martin, PhD Faculty of Pharmaceutical, Biomedical & Veterinary Sciences, University of Antwerp, Belgium. 4 months ago 21530 Views 1 comment

By Bronwen Martin

PubMed contains more than 29 million citations and billions of euros/dollars have been spent on funding biomedical research. So many advances have been made thanks to biomedical research. Yet, considering this multi-billion euro/dollar investment in biomedical research, have we really maximized its impact upon society? This is a question that we all have to ask ourselves.

If, tomorrow, you are diagnosed with a life-threatening disease such as ovarian cancer, dementia, Parkinson’s disease, etc. the odds are stacked against you as there are currently no effective treatments. Why is this? Is it because of a lack of brain power or funding? Possibly, possibly not. I would argue that it’s because of the way biomedical research is organized. Most diseases are complex and difficult to cure, but the current inefficient structure of biomedical research is hampering the search for effective treatments.

Biomedical researchers are far too often stuck in an endless cycle of writing/submitting grants and papers. There is an enormous emphasis on publishing papers, and universities and grant funders evaluate “productivity” by specific publication outputs (high impact factor journals, number of publications and citations). The actual nature of the work and the potential benefits for society are not the most important criteria in biomedical science appreciation. The repetition of incremental science advances in ever more esoteric niches is becoming the norm. This current biomedical research environment is not conducive for creating real societal impact.

We need to create a more healthy and effective biomedical research environment, where Open Science, Societal Impact and Teamwork are the criteria we want to see championed. Open Science and Societal Impact are closely intertwined and it is important that we make research more open, accessible and reproducible as this will enhance the likelihood of creating more societal impact.


So, how do we do this practically?

Actually, there are many easy ways for you to make biomedical research more open.

  • Publish articles that are Open Access. Other researchers, healthcare workers and patients can freely access and build upon your results. Interested in Open Access? Take a look at https://www.coalition-s.org
  • Use preprint servers. For biomedical sciences, bioRxiv (pronounced "bio-archive") is a free online archive and distribution service for unpublished preprints.
  • Deposit software code in a repository. For example, GitHub.
  • Make experimental protocols accessible. For example, through protocols io.
  • Deposit projects/data in repositories. For example, Zenodo.
  • Collaborate and share resources. Research institutions and grant funders need to reward researchers that share resources. How can this be done? Take a look at the San Francisco Declaration on Research Assessment (DORA).
  • Join or start an Open Science Community. Join like-minded people to determine how you can make your science more open and accessible. A good place to start is the Open Science Mooc Community (Mooc = Massive Open Online Course)


Creating real impact on our health, environment and society

Everyone in biomedical research has a responsibility to make research more relevant to the current societal needs and to create real-world impact. We need to stop focusing on ever-more specialized and esoteric publications and we need to emphasize the search for cures for debilitating diseases. To ‘borrow’ a phrase from John F. Kennedy: “Ask researchers not what the impact factors of their papers are, but ask how their work has impacted society.”

Biomedical research needs to be a greater team effort, where researchers, university systems, grant funders, policy makers, publishers and science companies work together to:

  • Identify the most pressing societal challenges
  • Give researchers adequate support and time to find real solutions to these challenges
  • Reduce administrative, paper/grant writing burdens to allow more time for creative thought
  • Reward researchers that work together, share resources and create real societal impact
  • Reward researchers that create an inclusive work environment and that actively and effectively mentor junior scientists
  • Develop better tools for research data dissemination and modernize and speed up the publication process.

We owe it to patients and the taxpayers that fund biomedical research to focus more on creating tangible societal impact. We ALL need to play our part to make the biomedical research system more efficient. Because, tomorrow… you, or a loved one, could be the patient that needs real-world results from biomedical research.

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This blog post is dedicated to Lynn Martin, who died of bile duct cancer in 2007 at age 54. Now, in 2019, there is still no effective treatment for bile duct cancer.

Bronwen Martin, Ph.D. is a mom of three young kids and works as Scientific Editor in the Faculty of Pharmaceutical, Biomedical and Veterinary Sciences at the University of Antwerp, Belgium. Prior to that, she was a Principal Investigator and Head of the Metabolism Unit at the National Institute on Aging, National Institutes of Health, Baltimore, MD USA.

Follow Bronwen on Twitter: @BronwenMMartin

Do you have suggestions on how we can make science more open and create more societal impact? Let us know in the comments!

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Stuart Maudsley 4 months ago at 06:08
Excellent blog, we need more people to consider what biomedical science is really for - it's not just about the grant-paper-grant cycle, it's about delivering impact to patients.....