Bosutinib

(HB1323)

Product overview

  • Name
    Bosutinib
  • Short description
    Abl / Src kinase inhibitor
  • Biological description
    Abl and Src kinase inhibitor (IC50 values are 1.2 and 2.4 nM for Src and Abl respectively). Selective for Src family kinases. Shows actions against chronic myeloid leukemia (CML). Shows antiproliferative and anti-tumor actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
  • Molecular Weight
    530.45
  • Molecular Formula
    C26H29Cl2N5O3
  • CAS Number
    380843-75-4

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bosutinib

  • Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia.

    Amsberg GK et al (2013) Onco Targets Ther 6 : 99-106.
    PubMedID: 23493838
  • Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.

    Boschelli DH et al (2001) J Med Chem 44(23) : 3965-77.
    PubMedID: 11689083

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