bpV(bipy)

(HB0144)

Product overview

  • Name
    bpV(bipy)
  • Short description
    Potent protein PTP inhibitor
  • Biological description
    Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 18 and 164 nM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 18 nM). Displays insulin-mimetic properties.
  • Biological action
    Inhibitor
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    Potassiumbisperoxo(bipyridine)oxovanadate(V)
  • Molecular Weight
    326.2
  • Chemical structure
    bpV(bipy)
  • Molecular Formula
    K[VO(O2)2C10H8N2]
  • CAS Number
    127393-89-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for bpV(bipy)

  • Inhibition Effects of Some Bioactive Peroxovanadium Complexes on the Tyrosine Phosphatase.

    Zhou XW et al (2000) Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(2) : 133-138.
    PubMedID: 12098789
  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.
    PubMedID: 8308031
  • Bisperoxovanadium compounds are potent PTEN inhibitors.

    Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
    PubMedID: 15147864
  • Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

    Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
    PubMedID: 9415395

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