Product overview

  • Name
    bpV(pic)
  • Short description
    Potent PTP inhibitor
  • Biological description
    Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 12.7 and 61 µM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 31 nM) and activates insulin-receptor kinase (IRK). Displays cardioprotective and insulin-mimetic properties.
  • Biological action
    Inhibitor
  • Purity
    >90%
  • Our products in action

Properties

  • Chemical name
    Dipotassium bisperoxo (picolinato)oxovanadate (V)
  • Molecular Weight
    367.28
  • Chemical structure
    bpV(pic)
  • Molecular Formula
    K2 [VO(O2)2C6H4NO2].2H2O
  • PubChem identifier
    16760324
  • SMILES
    C1=CC=NC(=C1)C(=O)[O-].O.O.[OH-].OO.OO.[K+].[K+].[V]

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water or DMSO

References for bpV(pic)

  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.
    PubMedID: 8308031
  • Bisperoxovanadium compounds are potent PTEN inhibitors.

    Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
    PubMedID: 15147864
  • Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

    Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
    PubMedID: 9415395
  • Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

    Tian Y et al (2012) Mol Med Rep 5(3) : 852-8.
    PubMedID: 22200881

Reviews & Product Guides