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Product overview

  • Name
  • Short description
    Potent PTP inhibitor
  • Biological description
    Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 12.7 and 61 µM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 31 nM) and activates insulin-receptor kinase (IRK). Displays cardioprotective and insulin-mimetic properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    Dipotassium bisperoxo (picolinato)oxovanadate (V)
  • Molecular Weight
  • Chemical structure
  • Molecular Formula
    K2 [VO(O2)2C6H4NO2].2H2O
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in water or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for bpV(pic)

  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.
    PubMedID: 8308031
  • Bisperoxovanadium compounds are potent PTEN inhibitors.

    Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
    PubMedID: 15147864
  • Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

    Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
    PubMedID: 9415395
  • Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

    Tian Y et al (2012) Mol Med Rep 5(3) : 852-8.
    PubMedID: 22200881
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