Product overview

Name Bradykinin
Alternative names BK
Purity >95%
Description Endogenous bradykinin receptor agonist
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Biological Data

Biological description

Bradykinin is an endogenous bradykinin receptor agonist with selectivity for B2 over B1 receptors.


Bradykinin interacts with its GPCRs (G-protein-coupled receptors) to induce changes in intracellular calcium via a variety of mechanisms (PLC, prostaglandins, protein kinases and PLA2). Addition of bradykinin to NG 108-15 neural cells causes a transient hyperpolarization followed by prolonged cell depolarization.

Recently Bradykinin has also been shown to neuron-generating division of neural progenitor cells through ERK activation


The peptide is involved in a variety of physiological and pathopysiological activities. It is a pro-inflammatory mediator and a potent vasodilator which exerts its vasodilatory actions by inducing endothelial release of NO (nitric oxide), prostacyclin and EDHF.


It is involved in cardiovascular homeostasis, inflammation and nociception. It also shows anti-proliferative and anti – fibrogenic effects.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >95%
Chemical name RPPGFSPFR
Molecular Weight 1060.22
Chemical structure Bradykinin | [58-82-2] Chemical Structure
Molecular Formula C50H73N15O11
CAS Number 58-82-2
PubChem identifier 439201
SMILES C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
InChiKey QXZGBUJJYSLZLT-FDISYFBBSA-N
Appearance Lyophilized powder

References for Bradykinin

References are publications that support the biological activity of the product
  • Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

    Pillat et al (2016) J Cell Sci. 129(18) : 3437-48
  • The kinin system--bradykinin: biological effects and clinical implications. Multiple role of the kinin system--bradykinin.

    Golias et al (2007) Hippokratia 11(3) : 124-8
  • Bradykinin receptors and their antagonists.

    Regoli et al (1998) Eur J Pharmacol. 348(1) : 1-10
  • Endothelial function and bradykinin in humans.

    Horning et al (1997) Drugs 2 : 42-7

4 Item(s)

Publications
These publications cite the use of Bradykinin purchased from Hello Bio:
  • The role of p21-activated kinase in hippocampal synaptic function

    Durazo Barba et al (2019) Bristol University : Thesis

1 Item