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Product overview

  • Name
  • Short description
    Endogenous bradykinin receptor agonist
  • Biological description

    Bradykinin is an endogenous bradykinin receptor agonist with selectivity for B2 over B1 receptors.

    Bradykinin interacts with its GPCRs (G-protein-coupled receptors) to induce changes in intracellular calcium via a variety of mechanisms (PLC, prostaglandins, protein kinases and PLA2). Addition of bradykinin to NG 108-15 neural cells causes a transient hyperpolarization followed by prolonged cell depolarization.

    Recently Bradykinin has also been shown to neuron-generating division of neural progenitor cells through ERK activation

    The peptide is involved in a variety of physiological and pathopysiological activities. It is a pro-inflammatory mediator and a potent vasodilator which exerts its vasodilatory actions by inducing endothelial release of NO (nitric oxide), prostacyclin and EDHF.

    It is involved in cardiovascular homeostasis, inflammation and nociception. It also shows anti-proliferative and anti – fibrogenic effects.

  • Alternative names
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Bradykinin | [58-82-2]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey
  • Appearance
    Lyophilized powder

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in water (1 mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Bradykinin

  • Bradykinin receptors and their antagonists.

    Regoli et al (1998) Eur J Pharmacol. 348(1) : 1-10
    PubMedID: 9650825
  • Endothelial function and bradykinin in humans.

    Horning et al (1997) Drugs 2 : 42-7
    PubMedID: 9429844
  • Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

    Pillat et al (2016) J Cell Sci. 129(18) : 3437-48
    PubMedID: 27528403
  • The kinin system--bradykinin: biological effects and clinical implications. Multiple role of the kinin system--bradykinin.

    Golias et al (2007) Hippokratia 11(3) : 124-8
    PubMedID: 19582206
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