BrdU (5-Bromo-2′-deoxyuridine)

(HB0979)

Product overview

  • Name
    BrdU (5-Bromo-2′-deoxyuridine)
  • Short description
    Thymidine analog. Widely used to identify proliferating cells.
  • Biological description

    Thymidine analog which is incorporated into DNA during DNA replication (during S-phase of cell cycle). 


    BrdU is used to identify proliferating cells. Labels cell lines and primary cell cultures in vitro and also cells in vivo. 


    Widely used to study adult neurogenesis. Can be used in combination with neuron specific markers such as NeuN to identify newly formed neurons.

    Frequently used to label and fate-map dividing cells in neural stem cell biology.


  • Alternative names
    5-BrdU, 5-bromo-2'-deoxyuridine, Broxuridine
  • Biological action
    Dyes & stains
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    5-Bromo-2-deoxyuridine
  • Molecular Weight
    307.1
  • Chemical structure
    BrdU  [59-14-3]
  • Molecular Formula
    C9H11BrN2O5
  • CAS Number
    59-14-3
  • PubChem identifier
    6035
  • SMILES
    C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Br)CO)O
  • Source
    Synthetic
  • InChi
    InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
  • InChiKey
    WOVKYSAHUYNSMH-RRKCRQDMSA-N
  • MDL number
    MFCD00006529
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    Soluble in water (50mM) and in DMSO (100mM)

References for BrdU (5-Bromo-2′-deoxyuridine)

  • Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors.

    Russo A et al (1984) Cancer Res 44(4) : 1702-5.
    PubMedID: 6704976
  • Neurogenesis in the adult human hippocampus.

    Eriksson PS et al (1998) Nat Med 4(11) : 1313-7.
    PubMedID: 9809557
  • The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival.

    Lehner B et al (2011) Cell Tissue Res 345(3) : 313-28.
    PubMedID: 21837406

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