Brilliant Blue G

(HB0716)

Product overview

  • Name
    Brilliant Blue G
  • Short description
    Non-competitive P2X7 antagonist. Protein-binding dye.
  • Alternative names
    Acid blue 90; Coomassie Brilliant Blue G; NSC 328382; CBBG
  • Biological description
    Non-competitive P2X7 antagonist (IC50 values are 10 and 200 nM at rat and human P2X7 respectively). Displays neuroprotective and anti-inflammatory properties. Also a protein binding dye causing a colour change from red to blue.
  • Biological action
    Dyes & stains
  • Our products in action

Properties

  • Chemical name
    Coomassie Brilliant Blue G (CBBG)
  • Molecular Weight
    854.02
  • Chemical structure
    Brilliant Blue G  [6104-58-1]
  • Molecular Formula
    C47H48N3NaO7S2
  • CAS Number
    6104-58-1
  • PubChem identifier
    http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6324599
  • SMILES
    CCN(CC1=CC(=CC=C1)S(=O)(=O)[O-])C2=CC(=C(C=C2)/C(=C/3\C=CC(=[N+](CC)CC4=CC(=CC=C4)S(=O)(=O)[O-])C=C3C)/C5=CC=C(C=C5)NC6=CC=C(C=C6)OCC)C.[Na+]

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (40mg/ml, at 20 oC) or methanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Brilliant Blue G

  • Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease.

    Ryu JK et al (2008) Neuroreport 19(17) : 1715-9.
    PubMedID: 18852683
  • Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors.

    Jiang LH et al (2000) Mol Pharmacol 58(1) : 82-8.
    PubMedID: 10860929
  • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

    Bradford MM (1976) Anal Biochem 72 : 248-54.
    PubMedID: 942051

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