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Biological Data Biological description Potent, selective D2 -like receptor agonist (Ki values are 5.3, 7.4, 454 and 645 nM at D2 , D3 , D5 and D1 receptors respectively). Prototypic antiparkinsonian agent. Active in vivo .
Solubility & Handling Storage instructions Room temperature
Solubility overview DMSO and Ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate
Chemical structure
Molecular Formula C32 H40 BrN5 O5 .CH3 SO3 H
SMILES [H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O
InChiKey NOJMTMIRQRDZMT-GSPXQYRGSA-N
References for Bromocriptine mesylate References are publications that support the biological activity of the product
Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. Lindgren HS et al (2009) Neuropsychopharmacology 34(12) : 2477-88. The D3 dopamine receptor: neurobiology and potential clinical relevance. Levant B (1997) Pharmacol Rev 49(3) : 231-52. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Sunahara RK et al (1991) Nature 350(6319) : 614-9.
Potent, selective D2 -like receptor agonist
![Bromocriptine mesylate [22260-51-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1813.png "Bromocriptine mesylate [22260-51-1]")
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