Product overview

Name Butyrolactone I
Purity >97%
Description Potent, selective CDK1, CDK2 and CDK5 inhibitor
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Biological Data

Biological description Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >97%
Molecular Weight 424.5
Chemical structure Butyrolactone I [87414-49-1] Chemical Structure
CAS Number 87414-49-1
SMILES CC(C)=CCc1cc(COC(=O)[C@]2(C)OC(=O)C(=C2c3ccc(O)cc3)O)ccc1O
InChiKey NGOLMNWQNHWEKU-UHFFFAOYSA-N
Appearance White to off-white solid