Product overview

  • Name
    BVT 948
  • Short description
    Non-competitive irreversible PTP inhibitor
  • Biological description
    Non-competitive irreversible protein tyrosine phosphatases (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits a broad spectrum of PTP's (IC50 values are 0.9, 1.7, 0.09, 1.5 and 0.7 µM for PTP-1B, TCPTP, SHP-2, LAR and YopH respectively). Inhibits several cytochrome P450 isoforms and suppresses MMP-9 and blocks TPA-induced NF-κB activation. Exhibits no activity for MAPK. Enhances insulin sensitivity. Cell permeable.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Molecular Weight
    241.25
  • Chemical structure
    BVT 948  [39674-97-0]
  • Molecular Formula
    C14H11NO3
  • CAS Number
    39674-97-0
  • PubChem identifier
    6604934
  • SMILES
    CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for BVT 948

  • Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.

    Liljebris C et al (2004) J Pharmacol Exp Ther 309(2) : 711-9.
    PubMedID: 14747616
  • Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.

    Hwang BM et al (2013) BMB Rep 46(11) : 533-8.
    PubMedID: 24152909

Reviews & Product Guides