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Calmidazolium Chloride


Product overview

  • Name
    Calmidazolium Chloride
  • Short description
    Calmodulin (CaM) antagonist
  • Biological description
    Calmodulin (CaM) antagonist. Inhibits calmodulin-dependent phosphodiesterase (IC50 = 0.15 µM). Antagonises Ca2+-transporting ATPase calmodulin-induced activation (IC50 = 0.35 µM). Inhibits adenylyl cyclase, soluble fusion protein, ACIX and ACV-ACII fusion proteins. Blocks L-type calcium channels as well as voltage-dependent Na+ and K+ channel currents; increases intracellular calcium. Shows cytotoxic and apoptotic effects.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    1-[Bis(4-chlorophenyl)methyl]-3-[2- (2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
  • Molecular Weight
  • Chemical structure
    Calmidazolium Chloride  [57265-65-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Calmidazolium Chloride

  • Comparison of the calmodulin antagonists compound 48/80 and calmidazolium.

    Gietzen K (1983) Biochem J 216(3) : 611-6.
    PubMedID: 6141789
  • Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium.

    Haunsø A et al (2003) Mol Pharmacol 63(3) : 624-31.
    PubMedID: 12606770
  • Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis.

    Kumar S et al (2009) Free Radic Biol Med 47(6) : 699-709.
    PubMedID: 19497364
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