Calphostin C

(HB0160)

Product overview

  • Name
    Calphostin C
  • Short description
    Potent, selective PKC inhibitor. Also antagonizes the Tcf/β-catenin complex
  • Biological description
    Potent and selective photo-activated PKC inhibitor (IC50 = 50 nM). Antagonizes the Tcf/β-catenin complex. Inhibits glioma tumour cell proliferation and protects the myocardium against ischemic injury.
  • Alternative names
    UCN 1028C|PKF 115-584
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
  • Molecular Weight
    790.76
  • Chemical structure
    Calphostin C  [121263-19-2]
  • Molecular Formula
    C44H38O14
  • CAS Number
    121263-19-2
  • PubChem identifier
    2533
  • SMILES
    CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO or ethanol

References for Calphostin C

  • The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.

    Pollack IF et al (1997) J Neurooncol 31(3) : 255-66.
    PubMedID: 9049854
  • The role of protein kinase in C ischemic/reperfused preconditioned isolated rat hearts.

    Tosaki A et al (1996) J Cardiovasc Pharmacol 28(5) : 723-31.
    PubMedID: 8945687
  • In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.

    Matsuzaki S et al (2013) PLoS One 8(4) : e61690.
    PubMedID: 23626717

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