CaM Kinase II (290-309), Calmodulin Antagonist

(HB0162)

Product overview

  • Name
    CaM Kinase II (290-309), Calmodulin Antagonist
  • Short description
    Potent, competitive CaMKII inhibitor
  • Biological description
    Potent and competitive CaMKII inhibitor (IC50 = 52 nM). Acts as a pseudosubstrate at the catalytic core of the enzyme. Reduces Ca2+-dependent Cl- current in T84 cells by approx. 70%, but does not affect Cl- channels in parotid acinar cells.
  • Biological action
    Inhibitor
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    Ca2+/calmodulin-dependent protein kinase II (290-309)
  • Molecular Weight
    2273.8
  • Molecular Formula
    C103H185N31O24S
  • CAS Number
    115044-69-4
  • PubChem identifier
    22114573
  • SMILES
    CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CCSC)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)N

Storing and Using Your Product

  • Solubility overview
    soluble in water

References for CaM Kinase II (290-309), Calmodulin Antagonist

  • Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.

    Payne ME et al (1988) J Biol Chem 263(15) : 7190-5.
    PubMedID: 2835367
  • Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II.

    Mukherji S et al (1995) J Biol Chem 270(23) : 14062-7.
    PubMedID: 7775466
  • Characteristics of the inhibitory effect of calmodulin on specific [125i]omega-conotoxin GVIA binding to crude membranes from chick brain.

    Ichida S et al (2000) Neurochem Res 25(12) : 1629-35.
    PubMedID: 11152392

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